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EC number: 236-337-7
CAS number: 13308-51-5
LLNA (according to OECD 429): not sensitising
disintegrations per minute per lymph node and the
stimulation index are given in Table 4.
The Stimulation Index
expressed as the mean radioactive incorporation for each
treatment group divided by the mean radioactive
incorporation of the vehicle control group are as
Concentration (%w/w) inpropylene glycol
observations and mortality data for test and control
animals are given in Table 5.
There were no deaths. No
signs of systemic toxicity were noted in the test or
control animals during the test.
Individual bodyweights and
bodyweight changes for test and control animals are
given in Table 6.
Bodyweight changes of the
test animals between Day 1 and Day 6 were comparable to
those observed in the corresponding control group
animals over the same period.
The skin sensitisation potential of boron orthophosphate was
assessed in a local lymph node assay (LLNA) according to OECD 429 and
under GLP (Bradshaw, 2013). Following a preliminary screening test in
which no clinical signs of toxicity were noted at a test concentration
of 50% w/w (suspended in propylene glycol), this concentration was
selected as the highest concentration in the main test. Three groups,
each of four mice, were treated with the test substance at
concentrations of 50%, 25% or 10% w/w to the dorsal surface of each ear
for three consecutive days. A further group was treated with the vehicle
control (propylene glycol). The thickness of each ear was measured
pre-dose on Day 1, post- dose on Day 3 and on Day 6. Five days following
the first application all mice were injected via the tail vein with
3H-methyl thymidine (3HTdR). Five hours later all mice were sacrificed
and the draining lymph nodes were excised and pooled for each
experimental group. 3HTdR incorporation was measured by
There were no deaths and no signs of systemic toxicity were noted
during the test.
The available data on skin sensitisation with boron
orthophosphate (CAS 13308-51-5) do not meet the criteria for
classification according to Regulation (EC) No 1272/2008, and are
therefore conclusive but not sufficient for classification.
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