Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-649-2
CAS number: 123-76-2
The corneal damage potential of the
substance was assessed by quantitative measurements of changes in
opacity and permeability in a bovine cornea, according to the OECD
Guideline 437. The test item was brought onto the cornea of a bovine eye
which had been incubated with cMEM without phenol red at 32 ± 1 °C for 1
hour and whose opacity had been measured. The test item was incubated on
the cornea for 10 minutes at 32 ± 1 °C. After removal of the test item
and 2 hours post-incubation, opacity and permeability values were
Under the conditions of this study, the
test item induced serious eye damage on the cornea of the bovine eye.
The calculated IVIS (in vitro irritancy score) was 84.29 which is within
the range for classification (according to the classification criteria
of OECD 437) of the substance as causing serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again