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EC number: 204-649-2
CAS number: 123-76-2
The acute toxicity of the test item was
investigated following a single oral administration to the Sprague
Dawley rat followed by a 14-day observation period. A first group of 3
female animals was initially dosed at 2000 mg/kg body weight (Step 1).
Mortality occurred in all animals on Day 2. Hunched posture,
piloerection and decreased activity were observed on the day of dosing.
A second group of 3 female animals was then dosed at lower dose level of
300 mg/kg (Step 2). No death occurred and no signs of toxicity were
seen. A third group of 3 female animals was then dosed at the same dose
level (300 mg/kg, Step 3). No death occurred and no signs of toxicity
were seen. No abnormalities were observed at necropsy examination in the
early decedent animals and in those sacrificed at the end of the
observation period. These results indicate that the test item induced
effects of toxicological relevance (mortality) in the rat following oral
administration of a single dose at 2000 mg/kg. No mortality nor signs of
toxicity were observed following dosing at 300 mg/kg. These results
indicate the acute toxicity estimate (ATE) to be greater than 300 but
lower than 2000 mg/kg body weight.
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