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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: inhalation
Data waiving:
other justification
Justification for data waiving:
the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Reason / purpose for cross-reference:
data waiving: supporting information
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 9th to 25th, 2017
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 104 (Vapour Pressure Curve)
according to guideline
EU Method A.4 (Vapour Pressure)
Principles of method if other than guideline:
Source of correction constants: E.D. Cater, Ch.2A, Physicochemical Measurements in Metal Research, Part 1, R.A. Rapp, Ed., John Wiley, New York, 1970
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
20 °C
Vapour pressure:
0.374 Pa
25 °C
Vapour pressure:
0.619 Pa

Vapour pressure of positive control at 30 °C: 1.80x10-1 Pa

Criteria for the vapour pressure of the positive control at 30 °C: 1.44x10-1 ± 0.1 Pa

The vapour pressure met the validity criteria. Therefore the study can be considered as valid.

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 3.71 x10-1 Pa

Vapour pressure at 25 °C: 6.19x10-1 Pa.

Vapour pressure: 0.374 Pa (at 20 °C), 0.619 Pa (at 25 °C)
Executive summary:

The vapour pressure of the test item was determined at four different temperatures (30, 45, 60 and 75 °C) according to the OECD Guideline 104 resp. EU A.4 using the effusion method (weight loss). Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p). Experiment 4 (nominal temperature 75 °C) showed no reproducible weight loss, because the cells were empty. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 12 % (limit value from the guideline 30 %) and good correlation. Therefore, the result of the test can be considered valid.

Vapour pressure at 20 °C: 3.74 x10 -01Pa

Vapour pressure at 25 °C: 6.19 x 10-01Pa

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion