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EC number: 204-649-2
CAS number: 123-76-2
The acute toxicity of the test material
was investigated following dermal administration of a single dose to the
rat, according to the OECD Guideline 402. A single dose of 2000 mg/kg
was administered to a group of 5 male and 5 female animals for 24 hours,
under semi-occlusive dressing. Animals were observed for mortality and
clinical signs and were weighed on the day of allocation, on the day of
dosing and on days 8 and 15. After 14 days, all animals were killed and
subjected to necropsy examination.
No mortality occurred and no signs of
toxicity were observed in male or female animals during the observation
period. The body weight changes observed during the study were within
the expected range for this species and age of animals. No significant
abnormalities were found at necropsy in the animals at termination of
the study. No abnormalities were observed at the treated site.
LD50 > 2000 mg/kg
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