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EC number: 217-496-1
CAS number: 1873-88-7
Log Kow: 6.2 at 20°C (QSAR)
A predicted log Kow value of 6.2 at 20°C was determined for
the substance using a validated QSAR estimation method. The result is
considered to be reliable. The calculated log Kow value was
supported by a measured log Kow of >6.5 extrapolated to 7.84
which was determined using a relevant form of the HPLC test method, but
lacking some corrective adjustment that would be necessary to validly
interpret the result. For organosilicon substances of this type,
validation studies have been conducted to develop appropriate HPLC
estimation methodology to determine log Kow. In addition to
non-standard mobile phase, a specific adjustment must be applied to
correct the resulting measured log Kow.
Octamethyltrisiloxane (L3, CAS No. 107-51-7) is a structural analogue of
the submission substance, 1,1,1,3,5,5,5-heptamethyltrisiloxane (H-L3,
CAS No. 1873-88-7). L3 has a measured log Kow of 6.6 at 25°C
using OECD 123 test method (slow stirring method) and it is expected
that H-L3 should have a slightly lower log Kow due to its
smaller molecular volume. Therefore, the predicted log Kow
result for H-L3 was selected as key study and used for assessment
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