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EC number: 217-496-1
CAS number: 1873-88-7
Table 1. Test results
Nominal concentration (μg/L)
Time-weighted mean measured
as % of nominal
0 (Solvent control)
0 (Pooled control)
There were no
statistically significant treatment-related effects
Long-term toxicity to fish: 90-d NOEC ≥0.027 mg/l (highest concentration
tested) (OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test))
read-across from read-across from an analogous/structurally related
substance, octamethyltrisiloxane (CAS 107-51-7).
There are no reliable long-term fish toxicity data available for
1,1,1,3,5,5,5 -heptamethyltrisiloxane (CAS 1873 -88 -7), therefore good
quality data for an appropriate structural analogue,
octamethyltrisiloxane (CAS 107-51-7), have been read across. A 90-d
NOEC of ≥0.027 mg/l (time-weighted mean measured concentration) (highest
concentration tested) have been determined for the effects of
octamethyltrisiloxane (CAS 107-51-7) on embryo survival, larval hatch
and growth (length and dry weight) of Oncorhynchus mykiss
(including a period of approximately 6 weeks after controls were
free-feeding). In view of the exposure regime it is likely that the test
organisms were exposed predominantly to the tested substance. Refer to
the discussion in the Section 6 endpoint summary (Section 7.0 of CSR)
for further discussion of the approach to chemical safety assessment for
this registration substance, and justification for read-across used.
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