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EC number: 217-496-1
CAS number: 1873-88-7
No skin sensitization data are available for the registered
substance 1,1,1,3,5,5,5,-heptamethyltrisiloxane, therefore good quality
data for the related substance octamethyltrisiloxane (L3, CAS 107-51-7)
have been read-across.
In a key skin sensitization study conducted according to OECD Test
Guideline 406 and in compliance with GLP, octamethyltrisiloxane was not
sensitising to the skin of guinea-pig (RCC 1999).
No skin sensitization data
were available for the registered substance,
1,1,1,3,5,5,5,-heptamethyltrisiloxane, therefore the key study for the
structurally analogous substance octamethyltrisiloxane (L3,CAS 107-51-7)
was used as read across.
Octamethyltrisiloxane has been tested in a Guinea-Pig Maximisation
test conducted according to OECD Test Guideline 406. During the
induction phase the guinea-pigs (10 test group and 5 control group,
males and females) were injected intradermally with 5% test substance in
olive oil and in an emulsion of FCA/physiological saline and thereafter,
topically treated with 100% test substance.
After a latency of 14 days, to allow a potential reaction of the
immune system, the animals were challenged with 50% of the test
substance in olive oil under occlusive dressing. The animals of the
control were induced with olive oil and FCA/physiological saline and
challenged similarly to those of the test group. Cutaneous reactions,
i.e., erythema and eschar, as well as oedema formation were evaluated at
24 and 48 hours after removal of the dressing. No toxic symptoms were
evident in the guinea pigs of the control or the test group. No deaths
occurred. None of the animals of the tes group were observed with
erythematous reactions after treatment with a test article concentration
of 50% in olive oil. Therefore the test article is considered not to be
a sensitizer when used under the described test conditions.
Based on the available data from the structurally analogous
substance octamethyltrisiloxane (L3, CAS 107-51-7), the registered
substance 1,1,1,3,5,5,5,-heptamethyltrisiloxane does not require
classification in accordance with Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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