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EC number: 217-496-1 | CAS number: 1873-88-7
Endpoint summary
Administrative data
Description of key information
Additional information
- A 96-hour LC50 value of >0.108 mg/l has been determined for the effects of the test substance on mortality of Brachydanio rerio (new name Danio rerio) based on geometric mean measured concentrations (Harlan, 2011b).
- A 48-hour EC50 value of >0.030 mg/l has been determined for the effects of the test substance on mobility of Daphnia magna based on geometric mean measured concentrations (Harlan, 2011c).
- A 72-hour EC50 value of >0.019 mg/l and NOEC of ≥0.019 mg/l have been determined for the effects of the test substance on growth rate and yield of Pseudokirchneriella subcapitata based on geometric mean measured concentrations (Harlan, 2011d).
- A 90-day NOEC of ≥0.027 mg/l (time-weighted mean measured concentration) has been determined for effects on embryo survival, larval hatch and growth (length and dry weight) in an early life-stage test with Oncorhynchus mykiss (Smithers Viscient, 2010).
- A 21-day EC50 value of >0.015 mg/l (arithmetic mean measured concentration) has been determined for effects on survival and mobility of Daphnia magna and a NOEC of ≥0.015 mg/l has been determined for effects on growth and reproduction (Wildlife International, 2010).
Reliable short-term toxicity tests results are available for freshwater fish (Brachydanio rerio), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata) for 1,1,1,3,5,5,5-heptamethyltrisiloxane (CAS 1873-88-7). The relevant short-term values are:
The water solubility limit of the test substance has been determined in a separate study to be 0.02 mg/l.
There are no long-term data for the registered substance. However, the following data are available for the structurally-analogous read-across substance octamethyltrisiloxane (CAS: 107-51-7):
There are no reliable data available for toxicity to microorganisms.
A 3 hour EC50 value of >100 mg/l (ASRI) is read-across from the structurally-related substance L4 (CAS 141-62-8) (Desmares-Koopmans, 2010).
Trimethoxysilane (CAS 2487-90-3) is used to support short-term toxicity to fish, aquatic invertebrates and algae endpoints, because it has an Si-H bond that will undergo the same reaction as the registration substance. E(L)C50 values of >100 mg/l for each species have been determined. Read-across from trimethoxysilane is not used to fulfil any data-gap, but is used to demonstrate that presence of the Si-H bond does not cause toxic effects.
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