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EC number: 217-496-1
CAS number: 1873-88-7
In an oral reproductive
screening study (combined with a repeated
dose toxicity study and developmental toxicity screening test),
to GLP and conducted according to OECD Guideline 422,
1,1,1,3,5,5,5-heptamethyltrisiloxane was assessed for its ability to
induce reproductive toxicity in Wistar rats.
of ten male and ten female rats were treated by oral gavage with the
test substance (in corn oil) at 0, 50, 200 or 800 mg/kg bw/day.
Following two weeks of treatment, animals were allowed to mate for up to
two weeks. In total, males were treated for at least 28 days (including
the pre-mating period of 14 days), while females were treated for
approximately 49 days (a pre-mating period of 14 days, a mating period
of up to 14 days, throughout gestation and up until 4 days post-partum).
Animals were observed throughout the study for any overt signs of
toxicity or morbidity, until sacrifice and gross necropsy. A number of
reproductive parameters were measured, including fertility and gestation
indices, mean precoital time, conception rate, duration of gestation,
corpora lutea, implantation rate, post-implantation loss and pup sex
survived until scheduled necropsy. Fertility index, gestation index and
conception rate were 100% in all groups and mean precoital time and
duration of gestation were unaffected by treatment. There were no
adverse effects of treatment with 1,1,1,3,5,5,5-heptamethyltrisiloxane
on fertility, and a no-observed-adverse-effect-level (NOAEL) of at least
800 mg/kg bw/day (the highest dose tested) was determined for toxicity
to reproduction on the basis of this screening test.
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