Registration Dossier
Registration Dossier
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EC number: 608-497-1 | CAS number: 3056-13-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15. april 2004 - 9. june 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented and reported study, conducted according to internationally accepted technical guideline. A GLP compliance statement and a Quality Assurance Uni Statement is included in the report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
Test material
- Reference substance name:
- [(2S,3R,5S)-3-[(4-methylbenzoyl)oxy]-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl 4-methylbenzoate
- EC Number:
- 608-497-1
- Cas Number:
- 3056-13-1
- Molecular formula:
- C26 H26 N2 O7
- IUPAC Name:
- [(2S,3R,5S)-3-[(4-methylbenzoyl)oxy]-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl 4-methylbenzoate
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- 0.46 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: Preliminary test; estimated by an Atom/Fragment Contribution Method
- Water solubility:
- 0.017 mg/L
- Temp.:
- 20 °C
- pH:
- >= 7.6 - <= 7.8
- Remarks on result:
- other: mean value of two measurements, standard deviation 0.0004
- Water solubility:
- 0.018 mg/L
- Temp.:
- 30 °C
Any other information on results incl. tables
The mean water solubility of test substance in water at 20 °C was
0.0172 mg/L, standard deviation 0.0009, 5 replicates, at a flow of 25.0 mL/h.
0.0167 mg/L, standard deviation 0.0012, 5 replicates, at a flow of 12.5 mL/h.
The mean water solubility was 0.0185 mg/L at 30.0 °C, standard deviation 0, 2 replicates, at a flow of 25.0 mL/h.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
