Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published study
Data source
Reference
- Reference Type:
- publication
- Title:
- Absence of Mutagenic Activity of Acidity Regulators in the Ames Salmonell microsome Tes
- Author:
- Al-Ani FY & Al-Lami SK
- Year:
- 1 988
- Bibliographic source:
- Mutation Research, 1988, Vol. 206, No. 4, 467-470
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- Principles of method if other than guideline:
- No further information
- GLP compliance:
- no
- Remarks:
- published study
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Orthophosphoric acid
- EC Number:
- 231-633-2
- EC Name:
- Orthophosphoric acid
- Cas Number:
- 7664-38-2
- IUPAC Name:
- phosphoric acid
- Details on test material:
- Phosphoric acid (breakdown product of phosphorus pentachloride following reaction with water)
Constituent 1
Method
- Target gene:
- Reversion to histidine independence
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 97
- Species / strain / cell type:
- S. typhimurium TA 98
- Species / strain / cell type:
- S. typhimurium TA 100
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- Concentrations up to 2.00 µg per plate
- Vehicle / solvent:
- Not stated
- Details on test system and experimental conditions:
- Phosphoric acid was tested for mutagenicity in the Ames Salmonella assay using strains (TA-97), (TA-98), (TA-100), and (TA-102) with or without metabolic activation from liver S9 mix obtained from male CD-COBS-rats pretreated with 0 to 100 mg/kg phenobarbital.
- Evaluation criteria:
- Not stated
- Statistics:
- Not stated
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Additional information on results:
- No additional information.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
No further remarks.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Neither citric acid, lactic acid, malic acid or phosphoric acid showed mutagenicity to any of the tester strains in the presence or absence of S9 mix . - Executive summary:
Neither citric acid, lactic acid, malic acid or phosphoric acid showed mutagenicity to any of the tester strains in the presence or absence of S9 mix.
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