Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
Endpoint summary
Administrative data
Description of key information
No study available for skin/eye irritation of PCl5 but assessment done based on its hydrolysis products.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data is available regarding skin and eye irritation for PCl5.
Howerver, there are some studies for phosphoryl trichloride (the first product of degradation of PCl5-See HSDB of PCl5) and for hydrochloric acid.
In this discussion only considerations regarding HCl are reported and not regarding H3PO4: H3PO4 and HCl are both hydrolysis products of PCl5 but the skin/eye irritation effects of HCl are higher than H3PO4 at the same concentration. According to the precautionary principle the assessment of skin/eye irritation of PCl5 is based on the hydrolysis product of higher concern (HCl).
Skin irritation
As reported in SIDS Dossier of POCl3 approved at SIAM 19 (19 -22 October 2004) with reference to Molodkina,Toksikol. Nov. Prom. Khim. Veshch. 13, 107-114, 1974, the rabbit skin treated with undiluted phosphoryl trichloride (4 drops per 20 cm²) showed skin scales, hemorrhagic fissures and a slowly healing wound.
As reported in SIDS Dossier of HCl approved at SIAM 15 (22 -25 October 2002) with reference to Potokar, Fd. Chem. Toxic., 23, 615-617, 1985, Hydrochloric acid 37% was corrosive after both 1 hr and 4 hr application of occlusive or semi-occlusive exposure on rabbits.
Eye irritation
As reported in SIDS Dossier of POCl3 approved at SIAM 19 (19 -22 October 2004) with reference to Molodkina,Toksikol. Nov. Prom. Khim. Veshch.13, 107-114, 1974, one drop of undiluted phosphoryl trichloride caused necrotic changes in the eye and complete blindness in rabbits.
As reported in SIDS Dossier of HCl approved at SIAM 15 (22 -25 October 2002) with reference to Jacobs, J. Am. Coll.Toxicol., 11, 6, 1992, hydrochloric acid 10% was classified as ‘Risk of serious damage to eyes’ according to the old 79/831/EEC Criteria (mean for six rabbits over 24/48/72 Hrs of iritis>1.5).Hydrochloric acid may cause severe irritation with corneal injury that may result in permanent impairment of vision.
Justification for selection of skin irritation / corrosion endpoint:
No study available for PCl5 but assessment done based on its hydrolysis products.
Justification for selection of eye irritation endpoint:
No study available for PCl5 but assessment done based on its hydrolysis products.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Phosphorus pentachloride is classified skin and eye irritant cat.1B (corrosive) according to annex VI CLP regulation (EC N.1272/2008).
No study is available for skin/eye irritation of PCl5 but assessment was done based on its hydrolysis products.
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