Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Toxicokinetics
No data are available. Phosphorus pentachloride reacts rapidly with water with the production of hydrochloric acid and phosphoric acid. In
aqueous (physiological) environments, the degradation products will dissociate to form physiologically ubiquitous ionic species (H+, Cl-, phosphate).
Acute toxicity
Molodkina (1973) reports an acute oral LD50 value of 600 mg/kg bw. This study is also summarised in a later review (Roshchin & Molodkina, 1977).
No data are available for acute dermal toxicity, however the corrosive nature of the test material means that the effects of dermal exposure will be dominated by local (site of contact effects); little or no systemic toxicity is predicted. Molodkina (1973) reports an acute inhalation LC50 value of 0.205 mg/l, for an unknown exposure period. This study is also summarised in a later review (Roshchin & Molodkina, 1977).
Irritation and corrosion
Phosphorus pentachloride is classified skin and eye irritant cat.1B (corrosive) according to annex VI CLP regulation (EC N.1272/2008).
No study available for skin/eye irritation of PCl5 but assessment was done based on its hydrolysis products.
Sensitisation
No data are available. Phosphorus pentachloride is classified skin and eye irritant cat.1B (corrosive) according to annex VI CLP regulation (EC N.1272/2008). As reported in column 2 REACH Annex VII the study does not need to be conducted if the available information indicates that the substance should be classified for skin sensitisation or corrosivity.
Genotoxicity
No data are available for the substance, however no genotoxicitiy is predicted. Negative results for the breakdown products hydrochloric acid and
phosphoric acid were obtained in a number of studies in vitro.
DNEL derivation
Insufficient data on repeated exposure are available for the derivation of a DNEL. The effects of the substance are predicted to be limited to local toxicity (irritation/corrosion) at the site of contact; no systemic toxicity is predicted due to the rapid breakdown of the substance in aqueous environments and the subsequent ionic dissociation of the breakdown products. Due to the corrosive nature of the substance, exposure should be minimised by the use of containment and protective equipment. DNEL derivation is not necessary.
However existing OEL values are available. EH40 /2005 Workplace Exposure Limits (UK HSE) reports values of 0.1 ppm (0.87 mg/m3) and 0.2 ppm (2 mg/m3) for long-term (8 -hour TWA) and short-term (15 -minute STEL) values respectively; these are considered to be adequately protective of local (respiratory tract) effects.
Further details are reported in specific endpoint summaries.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
The substance is used as transported isolated intermediate even though minor quantity is not under strictly controlled condition (<10 t/y) . No exposure of the general population is proposed and DNEL values are not derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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