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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published, public domain information
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Comparative Toxicity of Chloride Compounds of Phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures
Author:
Molodkina NN
Year:
1973
Bibliographic source:
Toksikologiya Novykh Prom, Khim, Veshch. 13: 107-114

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
No further details.
GLP compliance:
no
Remarks:
study pre-dates GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphorus pentachloride
EC Number:
233-060-3
EC Name:
Phosphorus pentachloride
Cas Number:
10026-13-8
Molecular formula:
PCl5
IUPAC Name:
pentachloro-λ⁵-phosphane
Details on test material:
No further details

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Mice are housed in a chamber of 100 liter capacity. Crystals of the test substance was administered to determine the lethal concentration of the test substance.

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Mice are housed in a chamber of 100 liter capacity. Crystals of the test substance was administered to determine the lethal concentration of the test substance.
Analytical verification of test atmosphere concentrations:
yes
Remarks:
colorimetry was used to determine the concentration of the test substance in the chamber.
Remarks on duration:
length of exposure not specified
Concentrations:
A range of concentrations were used to determine the lethal dose of phosphorus pentachloride.
No. of animals per sex per dose:
Not stated
Details on study design:
Crystals were introduced into a chamber of 100 liter capacity. The concentration of the test substance was determined by colorimetry.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 0.205 mg/L air (analytical)
95% CL:
ca. 0.152 - ca. 0.283
Remarks on result:
other: Exposure duration unknown
Mortality:
Not stated
Clinical signs:
other: On administering lethal concentrations of phosphorus pentachloride, unrest was observed at the outset; the animals struck their face with their paws and were excited. In 5-15 minutes, a depression of the animals sets in, there was lack of coordination of
Body weight:
In the course of several days after the administration, the surviving animals became sluggish, they refused their feed and lost weight.
Gross pathology:
Not stated.
Other findings:
No further findings.

Any other information on results incl. tables

The LC50 for phosphorus pentachloride was determined to be 0.205 mg/l.

Applicant's summary and conclusion

Interpretation of results:
other: acute toxicity cat.2
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The LC50 for phosphorus pentachloride in the rat was calculated to be 0.205 mg/l.
Executive summary:

The LC50 for phosphorus pentachloride in the rat was calculated to be 0.205 mg/l under the conditions of this study (unknown duration of exposure). Clinical signs observed after administration of the test substance included unrest, lack of coordination, fibrillar twitching, sweating, sharply reduced and laboured breathing. The substance is classified acute toxicity cat.2 according to the CLP regulation (EC N.1272/2008)