Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Phosphorus pentachloride reacts violently with water to produce hydrochloric acid and phosphoric acid. Testing for genotoxicity in vitro for PCl5 is therefore not practical. However both of the breakdown products are known to be non-genotoxic and will rapidly dissociate in aqueous environments with the formation of physiologically ubiquitous ionic species (H+, Cl-, phosphate).
Data regarding genotoxicity of HCl
Bacterial test
As reported in the study of Isquith et all, 1988 according to OECD 471 Ames test of HCl using several Salmonella typhimurium strains with and without S9 activation produced a negative result.
Non bacterial test
Different non bacterial tests for genotoxicity of HCl were conducted with negative result:
- sister-chromatid exchange assay using mouse lymphoma cells, with and without metabolic activation (mouse liver S9 homogenate)- Isquith et all, 1988 according to OECD 479
- mitotic recombination assay- Isquith et all, 1988 according to OECD 481
- chromosome aberration assay using mouse-lymphoma cells- Isquith et all, 1988 according to OECD 473
- DNA alkaline elution assay using mouse-lymphoma cells, with and without metabolic activation (mouse liver S9 homogenate) - Isquith et all, 1988 according to OECD 482
- gene mutations in mouse-lymphoma cells, with and without metabolic activation (mouse liver S9 homogenate)- Isquith et all, 1988 according to OECD 476
However, in SIDS Dossier of HCl approved at SIAM 15 (22 -25 October 2002) other non bacterial test with positive results are reported but they are considered to be artifacts due to low pH.
Data regarding genotoxicity of H3PO4
As reported in the study of Al-Ani FY & Al-Lami SK, 1988 according to OECD 471 phosphoric acid showed mutagenicity to any of the tester strains in the presence or absence of S9 mix. In SIDS Dossier of H3PO4 approved at SIAM 28 (15 -17 April 2009) other non bacterial tests for genotoxicity of phosphoric acid are reported all with negative results.
Conclusion
Genotoxiciy studies in vitro on the degradation products of PCl5 (hydrochloric acid and phosphoric acid) are clearly negative. No further testing is proposed. No genotoxicity effect is likely as the breakdown products are also present in the organism under normal physiological conditions.
Justification for selection of genetic toxicity endpoint
No study is available for PCl5 but assessment was done based on its hydrolysis products (HCl and H3PO4).
Short description of key information:
No study is available for PCl5 but assessment was done based on its hydrolysis products (HCl and H3PO4).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No study is available for genotoxicity of PCl5 but assessment was done based on its hydrolysis products (HCl and H3PO4). Genotoxicity data for HCl and H3PO4 are of none concern so no classification is proposed for genotoxicity of PCl5.
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