Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
Endpoint summary
Administrative data
Description of key information
Published studies of acute oral toxicity and acute inalation toxicity are available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 600 mg/kg bw
- Quality of whole database:
- Published study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 205 mg/m³ air
- Quality of whole database:
- Published study
Additional information
Acute oral toxicity
Molodkina (1973) reports an acute oral LD50 value of 600 mg/kg bw. This study is also summarised in a later review (Roshchin & Molodkina, 1977).
Acute dermal toxicity
No data are available, however the corrosive nature of the test material means that the effects of dermal exposure will be dominated by local (site of contact effects); little or no systemic toxicity is predicted.
Acute inhalation toxicity
Molodkina (1973) reports an acute inhalation LC50 value of 0.205 mg/l, for an unknown exposure period. This study is also summarised in a later review (Roshchin & Molodkina, 1977).
Justification for selection of acute toxicity – oral endpoint
Our judgement is based on two way of evidence studies. The two studies are similar.
Justification for selection of acute toxicity – inhalation endpoint
Our judgement is based on two way of evidence studies. The two studies are similar.
Justification for classification or non-classification
Phosphorus pentachloride is classified " Harmful if swallowed" (H302; oral acute toxicity cat.4) and "Fatal if inhaled" (H330;inhalation acute toxicity cat.2) according to the CLP regulation (EC N.1272/2008).
This classification is consistent with the results of the studies presented: no change to the existing classification is proposed.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
