Registration Dossier
Registration Dossier
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EC number: 233-060-3 | CAS number: 10026-13-8
Endpoint summary
Administrative data
Description of key information
There are no detailed studies available regarding repeated dose toxicity of PCl5. However different abstracts are reported in HSDB of PCl5 from which it is possible to suppose as weight of evidence that chronic inhalation exposure to PCl5 may cause damage to respiratory tract.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- Different abstract reported in HSDB of PCl5.
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
As reported in HSDB of PCl5 with reference to Sullivan et all, Hazardous Materials Toxicology-Clinical Principles of Environmental Health.Baltimore, MD: Williams and Wilkins, 1992, p.939 exposure to fumes of phosphorus trichloride and pentachloride may result in a chemical bronchitis with a chronic cough and/or wheezing. These declaration is based on chronic exposure to PCl5 in animals with the observation of squamative rhinitis, tracheitis and bronchitis. These effects were not reversible after cessation of exposure. Adverse effect of PCl5 on respiratory tract seem to be confirmed also on human in another study abstract reported in HSDB of HCl with reference to Rosenthal T et al; Chest 73 (5):623-6, 1978. Eleven people accidentally inhaled a significant amount of a gaseous mixture of hydrogen chloride, phosphorus oxychloride, phosphorus pentachloride, oxalyl chloride, and oxalic acid. Clinical observations and laboratory tests were recorded from the time of admission throughout hospitalization. The main abnormalities were found in the respiratory tract and consisted of clinical and physiologic evidence of obstruction ofthe airways, mild interstitial and alveolar edema, a defect in diffusion and inequalities of ventilation and perfusion that produced hypoxemia. All of these cleared within a short time.
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
Different abstracts are reported in HSDB of PCl5 from which as weight of evidence chronic inhalation exposure to PCl5 may cause damage to respiratory tract.
Justification for classification or non-classification
There are no detailed studies available regarding repeated dose toxicity of PCl5. However different abstracts are reported in HSDB of PCl5 from which it is possible to suppose as weight of evidence that chronic inhalation exposure to PCl5 may cause damage to respiratory tract. According to annex VI of CLP Regulation (EC n.1272/2008) PCl5 is classified H373 (specific target organ toxicity after repeated exposure cat.2).
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