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EC number: 701-247-3
CAS number: -
The ASA Category comprises the following 5 aromatic sulphonic acids:
TSA, Toluene-4-sulphonic acid (EC 203-180-0, CAS 104-15-4)
XSA, (Xylenes and 4-ethylbenzene) sulphonic acid (EC 701-247-3, CAS -) Former EC 246-839-8
CSA, p-cumene sulphonic acid (EC 240-210-1, CAS 16066-35-6)
BSA, Benzene sulphonic acid (EC 202-638-7, CAS 98-11-3)
HBSA, 4-hydroxybenzensulphonic acid (EC No. 202-691-6, CAS No. 98-67-9)
The skin sensitisation potential was assessed with available test on ASA and related salt (Hydrotropes substances). There is a single, key study for sensitization of the aromatic sulphonic acids performed on TSA. None of the tested animals showed positive responses in a, well documented, GLP guinea pig sensitization study (Hoechst, 1988). The test substance can be considered a non-sensitizer in guinea pigs as none of the test animals showed a positive response to combined intradermal and topical induction followed by topical challenge. The test on TSA was used in read across for XSA due to the chemical similarity between the two substances. Further supporting information of the sensitising potential can be derived by the analogous category of Hydrotropes, for which some members (Cumene and Toluene derivatives) have been tested always with negative results. The test on cumene sulphonate was used in read across for CSA and the test on STS is used to support the absence of sensitization effects of TSA.
Based on the chemical similarity among ASA and Hydrotropes substances it is reasonable to consider the substances of this two categories as not skin sensitizer.
See attached tables for details.
The skin sensitization potential of Toluene 4-sulphonic acid was assessed following official EU Method B.6, Skin sensitization. None of the tested animals showed positive responses and the test substance can be considered a non-sensitizer in guinea pigs.
There is no human or animal evidence of skin sensitization effects therefore no classification is requested based on Regulation (CE) 1272/2008.
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