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EC number: 701-247-3
CAS number: -
There are no dermal toxicity studies available for the aromatic sulfonic
acids. The dermal toxicity studies for the chemically similar
hydrotropes only local effects were observed. The derivation of systemic
DNEL's for all exposure routes will therefore be based on oral exposure
with adjustments made per OECD guidelines. The starting point was a 500
mg/kg bw/day NOAEL in a rat 28-day repeat dose study with oral exposure.
An overall assessment factor of 200 was derived combining a factor of 10
(interspecies), 10 (intraspecies, general population) and 2 (exposure
duration subchronic to chronic). The resulting dermal DNEL for the
general population is 2.5 mg/kg bw/day. The same valule is used for the
The general population inhalation starting point was the same study with
a NOAEL of 500 mg/kg bw/day. The corrected NOAEC was calculated
according to the RIP documents, considering allometric scaling, standard
respiratory volume and exposure duration.
The standard respiratory volume of rats is 0.2 L/min/rat = 0.8L/min/kg
assuming a standard rat is 250g.
0.38 m3/kg bw in 8 hours
1.15 m3/kg bw in 24 hours
The standard respiratory volume of humans is 0.2L/min/kg bw
The allometric scaling factor is 4 and the standard bw of a human = 70 kg
6.7 m3/person in 8 hours
20 m3/person in 24 hours
10 m3/worker in 8 hours (light work)
In oral studies, a 24h/d exposure period is assumed. For the
route-to-route extrapolation (i.e., oral to inhalation), the oral dose
is calculated as concentration in air, considering the standard
respiratory volume. It is assumed that both oral absorption and
inhalation absorption = 100%.
Corrected NOAEC(24h) = oral NOAEL/standard respiratory volume(24h)
= 500 mg/kg bw/d divided by 1.15 m3/kg bw
= 435 mg/m3
The corrected NOAEC of 435 mg/m3 is divided by an assessment factor of
50 (based on 2.5 for interspecies and remaining differences, 10 for
intraspecies, and 2 for exposure duration of subchronic to chronic).
The resulting DNEL inhalation = 8.7 mg/m3
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