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EC number: 701-247-3
CAS number: -
LD50 oral = 1410 mg/kg bw
Mortality: number of deaths at each dose: 2/5, 3/5 and 4/5 at 1250, 1600
and 2000 mg/kg for females, and 2/5 at 2000 mg/kg for males.
Time of death was Day 1 for all but one animal at 1600 mg/kg that died
on day 13.
Clinical signs: hypoactivity, hunched posture, irregular breathing were
observed in all animals from all dose groups on day 1 and was reversible
within 3 days for males at 2000 mg/kg. For females, the above symptoms
plus abnormal gait, ptosis and piloerection were seen in all animals at
1600 and 2000 mg/kg and were not reversible.
Necropsy findings: Red discolouration of the GI tract filled with blood,
white discolouration of the mucosa of the stomach and intestine, pale
adrenals, growing together of the stomach and nearby organs, stomach
haemorrhages and abdomen filled with fluid (in animals that died).
The key study is a 1988 GLP guideline study of male and female rats
exposed by oral gavage to toluene-4-sulphonic acid (CAS No, 104-15-4).
The LD50 value was 1410 mg/kg bw. Given the predominance of deaths
occurring within the day of exposure and the necropsy findings, it is
likely that the deaths were a result of the acidity / corrosivity of the
test substance. The internal examination findings (e.g., GI tract filled
with blood; stomach haemorrhages and abdomen filled with fluid) suggest
a secondary effect (i.e., corrosion) rather than a chemical toxicity.
In addition to the key study, there are 2 supporting acute oral studies
a 1977 test of xylenesulphonic acid (CAS No. 25321-41-9) and a 1962
published study of benzenesulphonic acid (CAS No. 98-11-3). Both of
these studies, as well as two additional published studies support the
LD50 value of 1410 mg/kg bw reported in the key study.
There are not data for dermal acute toxicity. The aromatic sulphonic
acids are corrosive and therefore with regard to animal welfare, dermal
studies are not recommended. There are however acute dermal toxcity
studies for the closely related hyrotropes that are the salt form of the
sulphonic acids. The LD50 for the salts is >2000 mg/kg bw.
A single acute inhalation study concluded the acids are harmful at
saturated air conditions as 3 of 6 animals died. A concentration was not
Since it is not possible to directly
assess the toxicity of sulphonic acids due to the corrosion/irritation
effects, read-across from the hydrotopes resdults could be taken into
studies with the salts (hydrotropes) provide valid read-across for the
acids. The specific cation is not expected to have an appreciable effect
on fate, ecotoxicity or mammalian toxicity and therefore the dataset for
the entire hydrotropes category can be applied broadly.
aromatic sulphonic acids are almost completely ionized in watery
environments even at low pH. The
salts of these acids are the hydrotropes (or “sulphonates”) which
include ammonium, calcium, potassium and sodium cations. In
principle the salts get dissociated when in contact with water, so
forming back to the acids. Because
of their close chemical similarities and because much of the production
of the aromatic sulphonic acids goes to manufacturing the salts, the
extensive dataset for the hydrotropes can also be used as a source of
read-across for endpoints in an aromatic sulphonic acid dossier. This
is particularly relevant for studies that are conducted in water (e.g.,
ecotoxicity and biodegradation) as well as for mammalian toxicity
studies where the relatively high acidity of the acid form has an
immediate and harsh local effect, whereas the salt form provides an
indication of potential systemic toxicity beyond the site of application
or initial contac
No basis for acute toxicity classification
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