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EC number: 701-247-3
CAS number: -
The modelling results show that the uptake of hydrotropes from either a
diluted solution, or the concentrated product, into the stratum corneum,
for short exposure durations varies between 0.36% and 0.55% of the
- % dermal absorption is independent of concentration (i.e., the dermal
flux is not saturated) and skin contact area
- % dermal absorption increases with duration exposure
- for all concentrations, the 23 hour uptake efficiency is ca 2.8% for
this exposure scenario (it is unlikely if not inconceivable that anyone
would be exposed to a solution containing a hydrotrope for 23 hours
without removal and/or washing of the exposed surface; therefore the
2.8% uptake efficiency would represent an upper bound value)
- a 2.8% dermal absorption factor can therefore be used as an upper
bound value in the exposure dose calculation
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