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EC number: 701-247-3
CAS number: -
3 additional animals were exposed for 3 minutes each. The mean erythema
score was 0.6 and the mean edema score was 0. Effect was reversible
within 72 hours.
The aromatic sulphonic acids, as
represented by toluene-4-sulphonic acid (CAS No. 104-15-4) and
hydroxybenzenesulphonic acid (CAS No. 1333-39-7) are corrosive to the
skin and eye.
A GLP guideline skin irritation study with
toluene-4-sulphonic acid conducted in 1988 indicated corrosive
properties after 4 hours of exposure; and the effects were not
reversible after 7 days. 3-minute exposures followed by washing with
water resulted in a much less severe effect that was reversible within
72 hours. During the test on sensitisation the primary skin irritation
effect of 0.01 -20% solutions of toluene-4-sulphonic acid
monohydrate in 0.9% NaCl solution was
studied. The animals was exposed 24 hours to an occlusive application.
An irritation effect was only found with 20%
, but in a study by Loden et al (1985)
with rabbits, without occlusion and after 4 hours, the same
concentration in pure water solution caused burns
A 1962, non-guideline eye irritation study
with a 65% solution hydroxybenzenesulphonic acid indicated corrosion of
the eye even after 5 seconds of exposure. There was no reversibility
indicated within 14 days.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Based on existing tests the substance is
classificated as "Corrosive" following Regulation 1272/2008. Based on
existing studies a tested concentration < 20% didn't caused burns or
irreversible effect. Therefore a concentration limit of 20% is set,
under that the substance can be classified as "Irritant"
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