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EC number: 701-247-3
CAS number: -
Precipitation concentration was >5000 micrograms per plate
Precipitation concentration 10,000 micrograms per liter
Mitotic Index: Concentration related plating efficiency was established
in 1000 cells from each of two slides per test group. No influence on
mitotic index was observed.
The precipitation concentration was > 1902 ug/mL
There is a fully documented, GLP Guideline
(OECD 471) Ames Test (Hoechst, 1988a) and a fully documented, GLP
Guideline (OECD 473) Chromosome Aberration Test (Hoechst, 1988b) for one
of the aromatic sulphonic acids, p-toluenesulphonic acid (CAS No.
tests were conducted with and without metabolic activation. The Ames
test exposed up to 5000 micrograms/plate and the chromosome aberration
test exposed up to 1902 micrograms per liter of the test substance.
These studies conclude the substance is neither mutagenic norcytotoxic.
There is an additional, published report
(Zeiger, 1988) of an Ames Test for another of the aromatic sulphonic
acids, benzenesulphonic acid (CAS No. 98-11-3). Exposures up to 10,000
micrograms/plate were done with and without metabolic activation. The
conclusion is the same as for the p-toluenesulphonic acid; that is, not
mutagenic and notcytotoxic.
There are no in vivo mutagenicity
studies for the aromatic sulphonic acids, but there are two in vivo mouse
micronucleusstudies for the related hydrotropes – sodium cumene
sulphonate (CAS 28348-53-0) (Sasol, 1992) and calcium xylene sulphonate
(CAS 28088-63-3) (Ruetgers-Nease, 1994). Both are GLP-compliant
Guideline mouse micronucleus studies with full documentation. The
Sasol study was an oral dose of 4467 mg/kg bw and the Ruetgers-Nease
study was an IP injection exposure of up to 580 mg/kg bw. Both studies
conclude the test substances were not mutagenic in these assays.
Short description of key information:
Endpoint Conclusion: No adverse effect observed (negative)
All study results are negative.
No classification for mutagenicity
is warranted under 67/548/EEC or Regulation 1272/2008.
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