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EC number: 202-826-9
CAS number: 100-18-5
This study investigated the potential toxicity of m-diisopropylbenzene
(m-DIPB) following repeated oral doses. The test material was
administered by oral gavage to groups of rats at doses of 0, 100, 300,
or 1000 mg/kg for 21 doses over 29 days. During this time, body weights,
food consumption, and clinical observations were recorded at weekly
intervals. At the conclusion of dosing, rats were sacrificed and
subjected to routine hematology, clinical chemistry, and
histopathological evaluations. m-DIPB was well tolerated when
administered by gavage. The exposure resulted in mild irritation to the
stomach and increased liver weights. The increase in liver weights was
probably an adaptive response since there was no indication of
degenerative effects on microscopic examination and no evidence of
increased serum enzyme levels. The significance, if any, of the changes
in glucose and creatinine levels in the high-dose males is unclear. The
changes in glucose and creatinine were within levels commonly
encountered in this laboratory and would not be considered clinically
significant. The significance of increased renal hyalin droplets in
males is also not clear. Based on previous experience, it appears that
the effect is probably due to exposure to the test substance but its
importance for human health evaluation is not known. Target organs
include the stomach due to direct contact, possibly the liver based on
increased organ weight, and possibly the kidneys based on the presence
of hyalin droplets. The no-effect level was close to but below 100 mg/kg.
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