Registration Dossier
Registration Dossier
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EC number: 202-826-9 | CAS number: 100-18-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
- Robilard, 1986: non-guideline study with m-diisopropylbenzene, exposure to 0.22 mg/L of test item, the highest concentration tested, had no observed inhibitory effects on the microorganisms. Thus, the NOAEC is 0.22 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 0.22 mg/L
Additional information
A radiorespirometric method was used to determine the compatibility of 1,3-Diisopropylbenzene with secondary waste treatment microorganisms (Robilard, 1986). The procedure used microorganisms from a laboratory-maintained activated sludge unit. These microorganisms were exposed to (14C) glucose and 1,3-Diisopropylbenzene. The extent of conversion of the (14C) glucose to (14C) carbon dioxide in the presence of the test article was compared to glucose conversion without test article. Exposure to 0.22 mg/L of 1,3-Diisopropylbenzene, the highest concentration tested, had no observed inhibitory effects on the microorganisms.
Based on the arguments presented in the Read Across statement attached in IUCLID Section 13, it is clear that the source and the target substances, which are structural isomers, show an identical toxicokinetic pattern and the data presented here can be used to fulfill the information requirements for the target substance 1.4-diisopropylbenzene.
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