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EC number: 202-826-9
CAS number: 100-18-5
The acute oral LD50 of this compound was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderat weakness and rough coats.
An acute oral toxicity study was conducted on rats. Based on the results of this study, the acute oral LD50 for test item was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderate weakness and rough coats.
It produced moderate to severe erythema and edema and some necrosis initially; eschars were present after one week, and scarring, desquamation and alopecia were present after two weeks at doses ranging from 20 mL/g down to 1 mL/kg.
The dermal LD50 was greater than 20 mL/kg.
The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20mL/kg bw (= ca. 20000 mg/kg bw/d).
Occluded, single dose:
The compound produced moderate to severe erythema and edema and some necrosis initially; eschars were present after one week, and scarring, desquamation and alopecia were present after two weeks at doses ranging from 20 mL/g down to 1 mL/kg.
Open, Reapead (10 Doses) - 5 animals:
Moderate to severe erythema and edema replaced by thick, broken eschars at day 10.
Skin Absorption possible
Repeated daily application (10) of 0.5 mL of the material moderately exacerbated the initial response. Moderate to severe erythema and edema and petechial hemorrhages were present at day 1. By day 10, the application site in all animals was characterized by thick, broken eschars. Absorption of the compound through the skin was possible, since three of five animals in the repeated skin application test lost weight over the course of the study.
p-diisopropylbenzene was a moderate skin irritant when applied to the depilated guinea pig abdomen under an occlusive wrap for 24 hours.
It produced moderate erythema, edema and some necrosis. Thin eschars at one week, light scarring desquamation and alopecia at 2 weeks.
The material did not elicit a positive response when administreed to ten guinea pigs in a standardized skin sensitization test.
A skin sensitisation test was performed on guinea pigs. The material did no elicit a positive response when administered to ten guinea pigs in a standardized skin sensitization test.
Consequently, estimated human risk is low and the test substance was determined to be non-sensitizing in guinea pigs.
The repeated dose toxicity test was done similar to OECD guideline 407. The test item was evaluated in a 2-week (subacute) oral toxicity study. Groups of five male rats were gavaged with 1000 or 100 mg compound/ kg/day for a total of eleven treatments over a 15 day span. A control group of five animals were gavaged with distilled water at a dose of 1000 mg/kg/day. The no effect level (NOEL) may be in the range of 100 mg/kg.
A very minor eye irritant.
The compound was a slight eye irritant when tested in six rabbit eyes (three washed and three unwashed). Irritation, limited to erythema of the adnexa, resolved after one hour. No adnexal or corneal staining was observed. Immediate washing was beneficial.
The eye irritation test was performed onto both eyes of 3 rabbits; in one eye of each rabbit, the material was immediately rinsed with water, while in the other eye, the material remained without washing. Immediately after instillation, slight erythema was observed that was limited to the adnexa, and washing was palliative. No adnexal or corneal staining was observed.
Based on the results observed in the present study, the criteria for classification and labelling according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 are not met.
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