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EC number: 202-826-9
CAS number: 100-18-5
Acute toxicity – oral/ rats Slightly toxic in oral route. LD50 > 3200 mg/kg body weight in male and female rats.
Acute toxicity – inhalation Not considered to be a relevant route of potential human exposure
Acute toxicity – dermal
Slightly toxic by the dermal route, LD50 > 20 mL/kg bw/d (= ca. 20000 mg/kg bw/d).
The acute oral LD50 of this compound was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderat weakness and rough coats.
An acute oral toxicity study was conducted on rats. Based on the results of this study, the acute oral LD50 for test item was greater than 3200 mg/kg in male and female rats. Clinical signs of toxicity included slight to moderate weakness and rough coats.
It produced moderate to severe erythema and edema and some necrosis initially; eschars were present after one week, and scarring, desquamation and alopecia were present after two weeks at doses ranging from 20 mL/g down to 1 mL/kg.
The dermal LD50 was greater than 20 mL/kg.
The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20mL/kg bw (= ca. 20000 mg/kg bw/d).
Acute toxicity – oral The acute toxicity of p-DIPB to rats in oral gavage test was performed. No compound-related effects were observed at gross pathology examination of the high-dose group of animals.
The compound was considered to be slightly toxic following oral administration. The LD50 value was greater than 3200 mg/kg body weight.
Acute toxicity – inhalation Inhalation is not considered to be a relevant route of potential human exposure
Acute toxicity – dermal The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route.
There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20 mL/kg bw (= ca. 20000 mg/kg bw/d).
Based on the available data, test item is not classified for acute toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
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