Registration Dossier
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EC number: 202-826-9 | CAS number: 100-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: older study; not conducted in accordance with current GLP guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1600, 3200 mg/kg
- No. of animals per sex per dose:
- four
- Control animals:
- no
- Details on study design:
- An acute oral toxicity study was conducted with two groups of four male and four female rats. Animals were fasted overnight prior to administration of the test substance. Dose levels were 1600 and 3200 mg/kg. At study start, animals weighed 170 to 226 grams. The test substance was administered neat by stomach tube.
- Preliminary study:
- Immediately after dosing, all animals appeared slightly weak. Slight to moderate weakness and roughened hair coats were noted at one hour, and slight weakness and rough hair coats were noted at two hours after dosing. By four hours after administration of the test substance, no abnormal clinical signs were observed in either sex at either dose level. No further abnormal clinical signs were observed at any time during the fourteen-day observation period. All animals gained weight during the study. No necropsies were conducted.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- Immediately after dosing, all animals appeared slightly weak. Slight to moderate weakness and roughened hair coats were noted at one hour, and slight weakness and rough hair coats were noted at two hours after dosing. By four hours after administration of the test substance, no abnormal clinical signs were observed in either sex at either dose level. No further abnormal clinical signs were observed at any time during the fourteen-day observation period.
- Body weight:
- At study start, animals weighed 170 to 226 grams.
- Gross pathology:
- No necropsies were conducted
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on the results of this study, the acute oral LD50 for p-diisopropylbenzend was greater than 3200 mg/kg in male and female rats.
- Executive summary:
An acute oral toxicity study was conducted with two groups of four male and four female rats. Animals were fasted overnight prior to administration of the test substance. Dose levels were 1600 and 3200 mg/kg. At study start, animals weighed 170 to 226 grams. The test substance was administered neat by stomach tube. Immediately after dosing, all animals appeared slightly weak. Slight to moderate weakness and roughened hair coats were noted at one hour, and slight weakness and rough hair coats were noted at two hours after dosing. By four hours after administration of the test substance, no abnormal clinical signs were observed in either sex at either dose level. No further abnormal clinical signs were observed at any time during the fourteen-day observation period. All animals gained weight during the study. No necropsies were conducted. Based on the results of this study, the acute oral LD50 was greater than 3200 mg/kg in male and female rats. This study was conducted between February 5 and March 1, 1982.
Reference
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: older study; not conducted in accordance with current GLP guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- the abdomens of six guinea pigs were depilated using a depilatory containing barium sulfide, talc, starch, and a commercial laundry detergent, wetted to make a thin paste. Following depilation, the animals were exposed dermally to doses of 1 (one animal), 5 (one animal), 1 0( one animal), or 20(three animals) mL/kg for 24 hours via gauze pads to which the appropriate amount of test substance had been applied. The pads were held in place by impervious rubber dental dam material wrapped around the torso of the animal and secured with rubber cement.
- Duration of exposure:
- 24 hours
- Doses:
- 1, 5, 10, 20 mL/kg
- No. of animals per sex per dose:
- 1 - 3
- Control animals:
- no
- Details on study design:
- The skin was evaluated immediately after removal of the wrapping material and one and two weeks later.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- Immediately after the animals were unwrapped, clinical signsof irritation on all six animals included moderate to severe erythema, moderate to gross edema and some evidence of necrosis. At one week, thin, dried eschars covered the entire area of the application site for all six animals. By termination of the 14-day study, the application sites had small, scattered light eschars, desquamation, alopecia, and light scarring. The severity of the signs was not related to dose. All animals gained weight during the study.
- Body weight:
- At initiation of the study, the guinea pigs weighed between 475 and 593 grams.
- Gross pathology:
- Necropsies were not conducted
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based upon the results of this test, the acute dermal LD50 of p-diisopropylbenzene was determined to be greater than 20 mL/kg in guinea pigs.
- Executive summary:
In this study the abdomens of six guinea pigs were depilated using a depilatory containing barium sulfide, talc, starch, and a commercial laundry detergent, wetted to make a thin paste. Following depilation, the animals were exposed dermally to doses of 1 (one animal), 5 (one animal), 1 0( one animal), or 20(three animals) mL/kg for 24 hours via gauze pads to which the appropriate amount of test substance had been applied. The pads were held in place by impervious rubber dental dam material wrapped around the torso of the animal and secured with rubber cement. At initiation of the study, the guinea pigs weighed between 475 and 593 grams. The skin was evaluated immediately after removal of the wrapping material and one and two weeks later. Immediately after the animals were unwrapped, clinical signs of irritation on all six animals included moderate to severe erythema, moderate to gross edema and some evidence of necrosis. At one week, thin, dried eschars covered the entire area of the application site for all six animals. By termination of the 14-day study, the application sites had small, scattered light eschars, desquamation, alopecia, and light scarring. The severity of the signs was not related to dose. All animals gained weight during the study. The test substance was rated a moderate irritant under the conditions of this study, and the dermal LD50 was greater than 20 mL/kg. There were no indications of dermal absorption as weight gains were similar across dose levels, and no abnormal clinical signs were noted other than irritation at the application site. This study
was conducted between February 3 and March 3, 1982.
Reference
Additional information
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