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EC number: 202-826-9
CAS number: 100-18-5
An acute oral toxicity study was conducted with two groups of four male
and four female rats. Animals were fasted overnight prior to
administration of the test substance. Dose levels were 1600 and 3200
mg/kg. At study start, animals weighed 170 to 226 grams. The test
substance was administered neat by stomach tube. Immediately after
dosing, all animals appeared slightly weak. Slight to moderate weakness
and roughened hair coats were noted at one hour, and slight weakness and
rough hair coats were noted at two hours after dosing. By four hours
after administration of the test substance, no abnormal clinical signs
were observed in either sex at either dose level. No further abnormal
clinical signs were observed at any time during the fourteen-day
observation period. All animals gained weight during the study. No
necropsies were conducted. Based on the results of this study, the acute
oral LD50 was greater than 3200 mg/kg in male and female rats. This
study was conducted between February 5 and March 1, 1982.
In this study the abdomens of six guinea pigs were depilated using a
depilatory containing barium sulfide, talc, starch, and a commercial
laundry detergent, wetted to make a thin paste. Following depilation,
the animals were exposed dermally to doses of 1 (one animal), 5 (one
animal), 1 0( one animal), or 20(three animals) mL/kg for 24 hours via
gauze pads to which the appropriate amount of test substance had been
applied. The pads were held in place by impervious rubber dental dam
material wrapped around the torso of the animal and secured with rubber
cement. At initiation of the study, the guinea pigs weighed between 475
and 593 grams. The skin was evaluated immediately after removal of the
wrapping material and one and two weeks later. Immediately after the
animals were unwrapped, clinical signs of irritation on all six animals
included moderate to severe erythema, moderate to gross edema and some
evidence of necrosis. At one week, thin, dried eschars covered the entire
area of the application site for all six animals. By termination of the
14-day study, the application sites had small, scattered light eschars,
desquamation, alopecia, and light scarring. The severity of the signs
was not related to dose. All animals gained weight during the study. The
test substance was rated a moderate irritant under the conditions of
this study, and the dermal LD50 was greater than 20 mL/kg. There were no indications
of dermal absorption as weight gains were similar across dose levels,
and no abnormal clinical signs were noted other than irritation at the
application site. This study
was conducted between February 3 and March 3, 1982.
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