1,4-diisopropylbenzene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation / corrosion, other

Remarks:

in vivo study that was performed prior to current requirement for in vitro alternative testing

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

00099-62-7

Cas Number:

00099-62-7

IUPAC Name:

00099-62-7

Constituent 2

Reference substance name:

m-diisopropylbenzene

IUPAC Name:

m-diisopropylbenzene

Test animals

Species:

guinea pig

Strain:

Hartley

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5 mL

Duration of treatment / exposure:

24 hours

Observation period:

2 weeks

Number of animals:

five (5)

Results and discussion

In vivo

Results

Irritation parameter:

other: Observation

Score:

ca. 0

Max. score:

0

Remarks on result:

other: The was no numerical scoring used, but IUCLID TCC demands a value, so "0" was used as a placeholder.

Irritant / corrosive response data:

Slight or very slight edema was observed in one of 5 and 3 of 5 guinea pigs, respectively, at 24-48 hours after exposure to m-diisopropylbenzene. Edema was accompanied by moderate to severe erythema in 2 of 5 guinea pigs, and well-defined erythema in 2 of 5 guinea pigs. Moderate to severe erythema without edema was observed in one of 5 guinea pigs at 24-48 hours after exposure. For all test animals, there were no signs of edema or erythema at 2 weeks after exposure.

Any other information on results incl. tables

animal no.	finding	skin (post-exposure)
		24-48 hrs	2 weeks
1	erythema	mod-severe	normal
	edema		normal
2	erythema	well-defined	normal
	edema	very slight	normal
3	erythema	mod-severe	normal
	edema	very slight	normal
4	erythema	mod-severe	normal
	edema	slight	normal
5	erythema	well-defined	normal
	edema	very slight	normal

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

The test article, m-diisopropylbenzene, was determined to be slightly irritating

Executive summary:

Slight or very slight edema was observed in one of 5 and 3 of 5 guinea pigs, respectively, at 24-48 hours after exposure to m-diisopropylbenzene. Edema was accompanied by moderate to severe erythema in 2 of 5 guinea pigs, and well-defined erythema in 2 of 5 guinea pigs. Moderate to severe erythema without edema was observed in one of 5 guinea pigs at 24-48 hours after exposure. For all test animals, there were no signs of edema or erythema at 2 weeks after exposure. This compound was determined to be slightly irritating