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EC number: 202-826-9
CAS number: 100-18-5
A screening study was conducted in six guinea pigs to estimate dermal
irritation, dermal toxicity, and dermal absorption of the test
substance. In this study the abdomens of six guinea pigs were depilated
using a depilatory containing barium sulfide, talc, starch, and a
commercial laundry detergent, wetted to make a thin paste. Following
depilation, the animals were exposed dermally to doses of 1 (one
animal), 5 (one animal), 1 0( one animal), or 20(three animals) mL/kg
for 24 hours via gauze pads to which the appropriate amount of test
substance had been applied. The pads were held in place by impervious
rubber dental dam material wrapped around the torso of the animal and
secured with rubber cement. At initiation of the study, the guinea pigs
weighed between 475 and 593 grams. The skin was evaluated immediately
after removal of the wrapping material and one and two weeks later.
Immediately after the animals were unwrapped, clinical signs of
irritation on all six animals included moderate to severe erythema,
moderate to gross edema and some evidence of necrosis. At one week,
thin, dried eschars covered the entire area of the application site for
all six animals. By termination of the 14-day study, the application
sites had small, scattered light eschars, desquamation, alopecia, and
light scarring. The severity of the signs was not related to dose. All
animals gained weight during the study. The test substance was rated a
moderate irritant under the conditions of this study,
A 0.1 mL aliquot of p-diisopropylbenzene was instilled into both eyes of
3 rabbits; in one eye of each rabbit, the material was immediately
rinsed with water, while in the other eye, the material remained without
washing. Immediately after instillation, slight erythema was observed in
3 of 3 rabbits that was limited to the adnexa, and washing was
palliative. At one hour after instillation, all signs of irritation had
resolved in all rabbits.
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