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Registration Dossier
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EC number: 202-826-9 | CAS number: 100-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Remarks:
- in vivo study that was performed prior to current requirement for in vitro alternative testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: older study; not conducted in accordance with current GLP guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- guinea pig
- Strain:
- Hartley
- Type of coverage:
- occlusive
- Preparation of test site:
- other: depilated using barium sulfide/talc/starch/commercial laundry detergent
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 1, 5, 10, 20 mL/kg
- Number of animals:
- six
- Details on study design:
- The abdomens of six guinea pigs were depilated. Following depilation, the animals were exposed dermally to doses of 1 (one animal), 5 (one animal), 1 0( one animal), or 20(three animals) mL/kg for 24 hours via gauze pads to which the appropriate amount of test substance had been applied. The pads were held in place by impervious rubber dental dam material wrapped around the torso of the animal and secured with rubber cement. The skin was evaluated immediately after removal of the wrapping material and one and two weeks later
- Irritation parameter:
- overall irritation score
- Time point:
- other: 14 days
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritant / corrosive response data:
- At initiation of the study, the guinea pigs weighed between 475 and 593grams. Immediately after the animals were unwrapped, clinical signs of irritation on all six animals included moderate to severe erythema, moderate to gross edema and some evidence of necrosis. At one week, thin, dried eschars covered the entire area of the application site for all six animals. By termination of the 14-day study, the application sites had small, scattered light eschars, desquamation, alopecia, and light scarring. The severity of the signs was not related to dose. All animals gained weight during the study.
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance was rated a moderate irritant under the conditions of this study
- Executive summary:
A screening study was conducted in six guinea pigs to estimate dermal irritation, dermal toxicity, and dermal absorption of the test substance. In this study the abdomens of six guinea pigs were depilated using a depilatory containing barium sulfide, talc, starch, and a commercial laundry detergent, wetted to make a thin paste. Following depilation, the animals were exposed dermally to doses of 1 (one animal), 5 (one animal), 1 0( one animal), or 20(three animals) mL/kg for 24 hours via gauze pads to which the appropriate amount of test substance had been applied. The pads were held in place by impervious rubber dental dam material wrapped around the torso of the animal and secured with rubber cement. At initiation of the study, the guinea pigs weighed between 475 and 593 grams. The skin was evaluated immediately after removal of the wrapping material and one and two weeks later. Immediately after the animals were unwrapped, clinical signs of irritation on all six animals included moderate to severe erythema, moderate to gross edema and some evidence of necrosis. At one week, thin, dried eschars covered the entire area of the application site for all six animals. By termination of the 14-day study, the application sites had small, scattered light eschars, desquamation, alopecia, and light scarring. The severity of the signs was not related to dose. All animals gained weight during the study. The test substance was rated a moderate irritant under the conditions of this study,
Reference
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Remarks:
- in vivo study that was performed prior to current requirement for in vitro alternative testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: older study; not conducted in accordance with current GLP guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Eye irritation studies in the Kodak laboratory were conducted using a method similar to that described in the current OECD Guideline. However, the test material was administered to six, rather than three, rabbit eyes. Three of the eyes were subsequently washed, so the effect of washing on the subsequent development of irritant responses could be evaluated. The effect of washing is not evaluated in current Guideline studies.
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Irritation, limited to erythema of the adnexa, resolved after one hour. No adnexal or corneal staining was observed. Immediate washing was beneficial.
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based upon the findings of this study, p-diisopropylbenzene is slightly irritating to the eyes of rabbits.
- Executive summary:
A 0.1 mL aliquot of p-diisopropylbenzene was instilled into both eyes of 3 rabbits; in one eye of each rabbit, the material was immediately rinsed with water, while in the other eye, the material remained without washing. Immediately after instillation, slight erythema was observed in 3 of 3 rabbits that was limited to the adnexa, and washing was palliative. At one hour after instillation, all signs of irritation had resolved in all rabbits.
Reference
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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