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EC number: 203-618-0
CAS number: 108-80-5
typhimurium strains TA1535, TA1537, TA98, TA100 and Escherichia coli
strain WP2uvrA were treated with suspensions of the test item,
Monosodium cyanurate monohydrate, using both the Ames plate
incorporation and pre-incubation methods at five dose levels, in
triplicate, both with and without the addition of a rat liver homogenate
metabolising system (10% liver S9 in standard cofactors). The dose range
was determined in a preliminary toxicity assay and was 50 to 5000
μg/plate in the first experiment. The experiment was repeated on a
separate day (pre-incubation method) using the same dose range as
Experiment 1, fresh cultures of the bacterial strains and fresh test
vehicle (sterile distilled water) control plates gave counts of
revertant colonies within the normal range. All of the positive control
reference items used in the test induced marked increases in the
frequency of revertant colonies, both with or without metabolic
activation. Thus, the sensitivity of the assay and the efficacy of the
S9-mix were validated. The test item caused no visible reduction in the
growth of the bacterial background lawn at any dose level and was,
therefore, tested up to the maximum recommended dose level of 5000
μg/plate. A light, opaque oily test item film was observed under an
inverted microscope at 5000 μg/plate, this observation did not prevent
the scoring of revertant colonies. No significant increases in the
frequency of revertant colonies were recorded for any of the bacterial
strains, with any dose of the test item, either with or without
metabolic activation or exposure method.
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