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EC number: 203-618-0
CAS number: 108-80-5
convert the oral NOAEL into inhalatory NOAEC, a rat default respiratory
volume was used corresponding to the daily duration of human exposure
(sRVrat: 0.38 m3/kg bw/8h). For workers a correction was added for the
difference between respiratory rates under standard conditions
(sRVhuman: 6.7 m3 for an 8h exposure period) and under conditions of
light activity (wRV: 10 m3 for an 8h exposure period). Oral absorption =
100% and inhalation absorption assumed to = 100% as worse-case. Thus,
the corrected starting point for inhalation is: 154 mg/kg bw/d x (1/0.38
m3/kg bw/8h) x (6.7 m3 for 8h exposure /10 m3 for 8h exposure) = 271.52
mg/m3 for workers.
oral absorption = 100%
Dermal absorption = 10% (conservative value)
154 /0.38 x 6/24 = 101.32 mg/m3 (General population 24 h). Oral
absorption = 100%; inhalation absorption assumed = 100%
To convert the oral NOAEL into inhalatory NOAEC, a rat default
respiratory volume was used corresponding to the daily duration of human
exposure (sRVrat: 1.15 m3/kg bw/d). Oral absorption = 100% and
inhalation absorption assumed to = 100% as worse-case. Thus, the
corrected starting point for inhalation is: 154 mg/kg bw/d x (1/1.15
m3/kg bw/d) = 133.91 mg/m3.
Oral absorption = 100%
Dermal absorption = 1 0% (conservative)
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