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EC number: 203-618-0
CAS number: 108-80-5
Studies have been conducted on the absorption, distribution,
metabolism and excretion of radiolabelled sodium cyanurate (equivalent
to 77.5% CYA) after single i.v. and repeated oral administration. No
metabolism or accumulation was demonstrated in either of the two animal
studies in dogs and rats with 100% of the radioactive label recovered in
urine and faeces. Over 98% of the cyanuric acid was absorbed from the GI
tract. The findings of the animal studies are upheld in a pilot study in
humans ingesting swimming pool water where > 98% of a measured dose of
CYA was recovered in urine within 24 hours of dosing (Dufour et al
(2006). In oral ingestion studies in 2 volunteers, total recovery of
cyanuric acid was 21 and 21.2 mg and interpolated 90% excretion was at
3.1 or 3.5 h (t1/2~ 1 h). The volunteers ingested 100 ml of
water containing 214 ppm cyanurate (or 21.4 mg cyanurate) thus
essentially 100% was recovered in the urine.
In dermal absorption studies where human skin was tested with a
pool concentration of unlabelled cyanuric acid and chlorine, only 0.06
μg/cm2total cumulative absorption was detected over the
24 h exposure period (Moody 1993). Employing a value of 1.83 m2for
the total body surface area of a 70 kg human, would imply an exposure of
1.1 mg for a 24 h exposure period. Assuming a worse case maximum
exposure time of 5 h daily the data suggests that 0.2 mg/day would be
absorbed through a swimmers skin. For a standard water cyanuric acid
concentration of 55 ppm, 0.2 g of cyanuric acid would be contained in
3.6 mL pool water. Therefore exposure by the oral route could easily
supersede that of dermal.
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