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EC number: 203-618-0
CAS number: 108-80-5
S-triazinetriol had no
significant effect on survival, appearance or behaviour including
nesting and nursing behaviour. No
cross generational trends indicative of a test article effect on
parental body weight was noted, nor was food consumption affected.
A consistent cross generational
trend of increased water consumption was noted in high dose females,
which in the F1 and F2 generations was accompanied
by a concurrent increase in sodium control female values, although the
role of increased sodium intake versus that of cyanuric acid is unclear.
survival, general appearance, behaviour, mean body weights and food and
water consumption of retained F3 pups were uniform in all
study groups. Treatment
with s-triazinetriol at concentrations of 5375 ppm or less did not
induce significant fluctuations in reproductive or litter parameters.
indices, gestation length, litter size, pup survival to weaning and pup
weights at parturition and throughout lactation of treated groups,
including the sodium control were comparable to those of the controls.
increased incidence of calculi in the urinary bladder in 5375 ppm F2
males was related to the test article. The
findings with respect to female water consumption in the high-dose group
and the post-mortem urinary bladder findings in the high-dose F2
males had no biologically detrimental effect on the reproductive
potential of the parents or on the growth and development of the
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