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EC number: 204-279-1
CAS number: 118-82-1
Table 7.4.1: Summary of the
Sensitisation Response after Challenge
A range-finding test was
performed to determine the appropriate concentrations that could be used
for both intradermal and topical induction as well as topical challenge.
The first induction phase involved six intradermal injections. These
doses were comprised of pairs of injections of the test substance in
corn oil, the test substance combined with Complete Freund´s Adjuvant
and corn oil and the Adjuvant alone. A control group (ten animals) was
maintained under the same environmental conditions and received
injections of corn oil, corn oil combined with complete Freund´s
Adjuvant and Adjuvant alone. The second phase of induction was conducted
by topical application for a period of 48 hours. Two weeks after the
topical induction, a challenge dose of the test material was applied for
24 hours. Twenty-four and 48 hours after challenge patch removal, the
animals were scored for a sensitisation response. None
of the twenty test animals showed any positive response at either 24 or
48 hours after removal of the challenge patches.
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