Registration Dossier

Physical & Chemical properties

Particle size distribution (Granulometry)

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From January to March 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Deviations:
no
GLP compliance:
yes
Type of method:
sieving
Type of distribution:
volumetric distribution
Percentile:
D50
Mean:
< 100 µm
Remarks on result:
other: 92% of the test item have an inhalable particle size.(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)

Particle size data acquired for the test item:

 Measurements  Methods  Results
 Proportion oftest item having an inhalable particle size <100 µm  Sieve  92.0%
 Proportion oftest item having a thoracic particle size <10.0 µm  Cascade impactor  8.73%
 Proportion of test item having a respirable particle size <5.5 µm  Cascade impactor  2.39%
Conclusions:
According to the sieve method, 92% of the test item have an inhalable particle size (< 100µm). 2.39% of the particles had a particle size of < 5.5 µm
Executive summary:

According to the sieve method, 92% of the test item have an inhalable particle size (< 100µm). 2.39% of the particles had a particle size of < 5.5 µm

Description of key information

According to the sieve method, 92% of the test item have an inhalable particle size (< 100µm). 2.39% of the particles had a particle size of < 5.5 µm

Additional information

A study performed according to OECD Guideline 110 (Particle Size Distribution / Fiber Length and Diameter Distributions) revealed that 92% of the particles were below 100µm and 2.39% of the particles had a particle size of < 5.5 µm..Too few particles of a size < 10 µm were present to obtain a mass medium aerodynamic diameter.