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EC number: 204-279-1
CAS number: 118-82-1
1. No major adverse toxicological manifestations have been detected when
group mean results from a number of serum parameters are considered.
2. Evidence of raised serum glutamate-pyruvate transaminase (SGPT)
activity has been obtained in a number of subjects during the period of
test compound administration and again between 7 and 14 days of the
3. Minor elevations in serum calcium have been observed during test and
4. Minor reductions in Haemoglobin were observed in some Volunteers
during the period of test compound administration.
5. BRL 10901 lowered serum cholesterol by about 40 when Group 1 mean
results were considered. Reduced and variable hypocholesterolaemic
response was detected in Group 2 Volunteers. Poor response was obtained
in subjects with hypertriglyceridaemia and high levels of VLDL.
6. In association with the hypocholesterolaemic response discrete
reductions in serum phospholipids and inorganic phosphate were observed
during the period when test compound was administered.
7. Results obtained after standard test meal indicate that BRL 10901 is
effective in reducing the normal post-prandial elevation in serum
Cholesterol, Triglycerides, Phospholipids and Inorganic phosphates.
8. Significant reductions in serum beta lipoproteins and less marked
elevations in alpha lipoprotein fractions were observed in conjunction
with changes in serum cholesterol and phospholipids.
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