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EC number: 204-279-1
CAS number: 118-82-1
Weight Gain, Food intake, and Mortality over 90 days feeding
Dietary Additive Group
Wt. % added to diet
Mean wt. gain (per cent)
Mean daily food intake (grams)
- 3 + 4
A 90-day repeated dose feeding study was conducted in male and female
albino rats with antioxidant “Ethyl” 702 as the test substance, and
Butylated hydroxytoluene (BHT) as the positive control substance. Test
concentrations were control, 0.125, 0.5, 1.25 and 2.50 wt. percent of
the diet; BHT was tested at a single concentration of 1.25 wt. percent
of the diet. The purpose of the study was to examine
the effects of the test article to some aspects of toxicity seen with
other alkylated phenols. No grossly harmful effects
were seen in the animals exposed to test substance. No
significant differences were noted in the groups with respect to growth,
consumption of food, or apparent physiological activity. The
administration of BHT at a level of 1.25% of the diet caused death in
20% of the animals during the course of the study.
examinations of the test animals carried out in intervals of 30 days
disclosed no abnormalities in the numbers or types of leucocytes in
peripheral blood, in hematocrit, hemoglobin, or prothrombin times. These
findings of no effect was interpreted to mean that the test article did
not cause the cause the anticoagulative effects seen in rats fed some
other alkyl phenols in comparable diets. These
hemorrhagic tendencies were thought to be associated with an increase in
‘prothrombin time” and with the metabolism of Vitamin K seen in rats fed
some other alkyl phenols.
study determination, there were no adverse effects seen among the test
article treated groups with respect to survival or gross pathological
changes. There were significant effects in the final
weights of females in the various groups (the test substance treated
animals had heavier than control weights), and in the final weights of
individual viscera. That is, the larger animals had
heavier viscera, and vice versa, but without a uniform proportional
relationship of body weight to weight of organs.
histopathologic examination of viscera and endocrine glands of these
rats revealed no changes in the groups 0.125%, 0.5%, or 1.25% test
article in the diet. Slight degeneration of the liver
was observed at the dietary concentration of 2.5% test article in the
diet in about 30% of the animals in the group. Comparatively,
marked degeneration of the livers was found in almost all of the rats
fed BHT at 1.25% in the diet.
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