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EC number: 211-889-1
CAS number: 705-86-2
Body Weight, Clinical Signs and Necropsy Findings:
Body weight (kg)
At Start of
No Abnormality Detected F:
Ante Meridian PM:
Post Meridian h:
There are no pre-terminal deaths
Animals Eye Irritation Scores (Treated Eyes):
Area of Opacity
NA: Not applicable
Scores - Mean Values of all Animals (Treated Eye):
The acute eye irritation / corrosion
study in New Zealand White rabbits was conducted to evaluate the eye
irritation / corrosion potential of Decan-5-Olide (CAS:705 -86 -2):
Acute Eye Irritation / Corrosion study in New Zealand White Rabbits"
when a single dose of the test item was instilled into the conjunctival
sac of the rabbit’s eye according to OECD 405 guideline. On test day one
(treatment day), a volume of 0.1 mL of undiluted test item was instilled
into the conjunctival sac of the left eye of the animal after gently
pulling the lower lid away from the eyeball. The lids were then held
together gently for about one second to prevent loss of test item. The
right eye remained untreated and served as the reference control. All
the rabbits were treated in a similar manner. The rabbit used for the
single animal test was observed for a period of 5 days and the
additional two rabbits were observed for a period of 4 days
post-instillation. The eyes of each rabbit were examined examined by
using an ophthalmoscope at 1, 24, 48 and 72 hours post-instillation and
scored. The rabbits were observed for clinical signs and pre-terminal
deaths twice daily with a minimum of 6 hours gap between observations on
days 2 to 5/4. Body individual weights were recorded at the start of
acclimatization, day 1 of treatment (prior to test item instillation)
and at the termination of the observation period. The individual mean
score for animal nos. 1, 2 and 3 at 24, 48, 72 hours (at treated
site)for corneal opacity, iris, conjunctiva and chemosis were found 0
respectively. There were no clinical signs of toxicity and pre-terminal
death, body weights of all rabbits increased during the observation
periodand no abnormality was detected at necropsy.Based on the present
study results the test itemDecan-5-Olideis“Non - irritant to Eyes”ofthe
eye of New Zealand white rabbits.
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