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EC number: 211-889-1
CAS number: 705-86-2
IndividualBody Weights, Body Weight
Change, Clinical Signs, Pre-terminal Deaths and Necropsy Findings
Body weights (kg)
Body weight change#
No Abnormality Detected N:
Observation of clinical signs is applicable for throughout the
[At Termination - At Treatment]
Skin Reaction Scores:
Observations (post removal of the 4-hour test patch)
No Erythema / No Edema
responses (skin reactions) were assessed immediately after the removal
of the test patches at 3 minutes, 1 hour and 4thhour after
application the score of erythema and edema was “0” and it indicated
that the test item was not severely irritating or corrosive
The acute skin irritation / corrosion
study in New Zealand White Rabbits was conducted to evaluate the skin
irritation potential of Decan-5-Olide according to OECD 404 guidline.
Three healthy young adult male rabbits were used for the study. Body
weights were recorded on day of treatment (prior to application) and at
termination. Rabbits with good intact skin were selected for the study.
The fur on the left side of the dorsolateral trunk surface [about 19 x
14 cm] was clipped with an electric clipper, approximately 24 hours
prior to treatment. A volume of 0.5 mL of the undiluted test item was
applied in between the prepared area of the skin and the cotton gauze of
size approximately 6 cm2 (2 x 3 cm of 6 ply). A control
patch (bare cotton gauze) was applied 3 – 4 cm anterior to the 4-hour
test patch. All the patches were secured to the body of the animal by an
adhesive tape, and a crepe bandage (except for 3 minutes patch) was
wrapped around the torso of the animal. After 4 hours contact period,
the treated area was washed with de-ionized water. The study was
conducted in a stepwise manner (i.e., one rabbit for the initial test
and two rabbits for the confirmatory test). The degree of irritation was
evaluated at 1, 4, 24, 48 and 72 hours post removal of the test patch.
The total mean score of skin reaction was 0 at 1, 24, 48, 72 hours
respectively post removal of the test patch. There were no clinical
signs and no pre-terminal deaths in any of the rabbits. No abnormalities
were detected at necropsy.Based on the present study results,the test
item,Decan-5-Olideis considered as“Non-irritant”to
the skin of New Zealand White rabbits.
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