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EC number: 211-889-1
CAS number: 705-86-2
Classification of Decan-5-olide for
effects in the environment:
The chemical Decan-5-olide (CAS no.
705-86-2) is used as a flavouring agent in food, cosmetics and perfumery
etc.The aim was to assess whether the PBT criterion within Annex XIII
was fulfilled forDecan-5-olide. The PBT criterion was herein assessed
based on experimental data in conjunction with standardized
environmental fate models. Here follows a description of the PBT
The tested substance does not
fulfil the P criterion within Annex XIII based on the assessment that
28-days Closed Bottle test following
the OECD guideline 301 D to determine the ready biodegradability of the
test item Decan-5-olide (CAS No.705-86-2). The study was performed at a
temperature of 20°C. The test system included control, test item and
reference item. Polyseed were used for this study. 1 polyseed capsule
were added in 500 ml D.I water and then stirred for 1 hour for proper
mixing and functioning of inoculum. This gave the bacterial count as 107
to 108 CFU/ml. At the regular interval microbial plating was also
performed on agar to confirm the vitality and CFU count of
microorganism.The concentration of test and reference item (Sodium
Benzoate) chosen for both the study was 4 mg/L, while that of inoculum
was 32 ml/l. OECD mineral medium was used for the study. ThOD
(Theoretical oxygen demand) of test and reference item was determined by
calculation. % degradation was calculated using the values of BOD and
ThOD for test item and reference item. The % degradation of procedure
control (reference item) was also calculated using BOD & ThOD and was
determined to be 73.49% at 20 ± 1°C. Degradation of Sodium Benzoate
exceeds 43.37% on 7th days & 58.43% on 14th day. The activity of the
inoculum is thus verified and the test can be considered as valid. The
BOD28 value of test chemical Decan-5-olide was observed to be 1.25
mgO2/mg. ThOD was calculated as 2.53 mgO2/mg. Accordingly, the %
degradation of the test item after 28 days of incubation at 20 ± 1°C
according to Closed Bottle test was determined to be 49.4%. Based on the
results, the test item, under the test conditions, was considered to be
ultimate inherently biodegradable in nature.
Thus, based on the available
information of the test chemical Decan-5-olide, it has been concluded
that chemical Decan-5-olide is likely to be not persistent (not P) in
According to the fugacity model levels
III, the most likely environmental fate for this test chemical is soil (i.e.estimated
to 71.1%). In soil, Decan-5-olide was expected to have negligible to
slow mobility based upon a Log KOC value of 3.698, respectively. The
half-life in soil (17.33 days estimated by EPI suite) indicates that the
chemical is not persistent in soil and the exposure risk to soil
dwelling animals is moderate to low.
If released in to the environment,
24.9% and 0.205% of the chemical will partition into water and sediment
according to the Mackay fugacity model level III in EPI suite version
4.1 (2017). However, the half-life (8.66 days in water & 77.916 days in
sediment estimated by EPI suite) indicates that the chemical is not
persistent in water and sediment & the exposure risk to aquatic and
sediment dwelling animals is moderate to low.
Hence it has been concluded that
chemical Decan-5-olide is not persistent in nature.
The tested substance does not
fulfil the B criterion within Annex XIII based on the assessment that
Theestimated BCF value from
authoritative database was determined to be ranges from 22.95 to 40.5,
respectively and theoctanol water partition coefficient of the test
chemical was determined to be 2.27, respectively which is less than the
threshold of 4.5. If this chemical is released into the aquatic
environment, there should be a low risk for the chemical to
bioaccumulate in fish and food chains.
The tested substance does not
fulfil the T criterion within Annex XIII based on the assessment that
The tested chemical is regarded to be
not classified for carcinogenicity, mutagenicity and reprotoxicity,
Further, there is no evidence of chronic toxicity, as identified by the
classifications STOT (repeated exposure), category 1(oral, dermal,
inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2
(oral, dermal, inhalation of gases/vapours, inhalation of
All of the available short-term
eco-toxicity data for fish, invertebrates and algae for the substance Decan-5-olide
indicates the LC50/EC50 value to be in the range 6.25 to 30.1 mg/L,
respectively. These value suggest that the substance is likely to be
hazardous to Aquatic organisms at environmentally relevant
concentrations and can be considered to be classified ‘Aquatic Chronic
Category 2’ as per the CLP regulation.
On the basis ofthe estimated data of long
term eco-toxicity data for fish and aq. Invertebrates, the NOEC value
was estimated to be ranges from 2.92 to 4.5 mg/l, respectively. By
speculation, long-term NOEC for aquatic organisms were not expected for
the substance at concentration below 0.01 mg/L based on the data
The chemical was therefore not
considered as hazardous to aquatic environments as per the criteria set
out in Annex XIII.
Based on critical, independent and
collective evaluation of information summarized herein, the tested
compound does not fulfil the P, B and T criterion and has therefore not
been classified as a PBT compound within Annex XIII.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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