Registration Dossier
Registration Dossier
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EC number: 414-780-9 | CAS number: 38585-74-9 A-87440.0; A-87440.00
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Mar 1995 to 17 Mar 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out in accordance with method C7 of commission directive 92/69/EEC and in accordance with GLP. The test material was well characterised
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-thiazolylmethanol
- EC Number:
- 414-780-9
- EC Name:
- 5-thiazolylmethanol
- Cas Number:
- 38585-74-9
- Molecular formula:
- C4H5NOS
- IUPAC Name:
- (1,3-thiazol-5-yl)methanol
Constituent 1
Study design
- Analytical monitoring:
- yes
- Buffers:
- pH4, pH7 and pH9.
- Details on test conditions:
- Incubated at 50 C and pH 4.00, 7.00 and 9.00
- Number of replicates:
- Two
- Negative controls:
- yes
- Remarks:
- Buffers 4, 7 and 9
Results and discussion
- Preliminary study:
- A-87440.0 did not undergo any hydrolysis over a period of 5 days at 50°C.
- Test performance:
- The results indicate that at 25°C, the test substance will produce half-life times of greater than 1 year at pH4, 7 and 9.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Test material is predicated to have a half-life of longer than one year in conditions most representative of those in the environment (25 C).
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