Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Mar 1995 to 17 Mar 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study carried out in accordance with method C7 of commission directive 92/69/EEC and in accordance with GLP. The test material was well characterised

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report Date:
1995

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical monitoring:
yes
Buffers:
pH4, pH7 and pH9.
Details on test conditions:
Incubated at 50 C and pH 4.00, 7.00 and 9.00
Number of replicates:
Two
Negative controls:
yes
Remarks:
Buffers 4, 7 and 9

Results and discussion

Preliminary study:
A-87440.0 did not undergo any hydrolysis over a period of 5 days at 50°C.
Test performance:
The results indicate that at 25°C, the test substance will produce half-life times of greater than 1 year at pH4, 7 and 9.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Test material is predicated to have a half-life of longer than one year in conditions most representative of those in the environment (25 C).