Registration Dossier
Registration Dossier
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EC number: 414-780-9 | CAS number: 38585-74-9 A-87440.0; A-87440.00
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 17 - June 09, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- and 21 CFR 28
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 5-thiazolylmethanol
- EC Number:
- 414-780-9
- EC Name:
- 5-thiazolylmethanol
- Cas Number:
- 38585-74-9
- Molecular formula:
- C4H5NOS
- IUPAC Name:
- (1,3-thiazol-5-yl)methanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles Rivers
- Age at study initiation: 4 - 7 weeks
- Weight at study initiation: 112 to 134 g- male; 118-138 g-females
- Fasting period before study: overnight.
- Housing: individually in hanging stainless steel cage
- Diet: Certified Rodent Chow ad libitum
- Water: tap water ad libitum
- Acclimation period: 6 days before
ENVIRONMENTAL CONDITIONS
- Temperature: 71 - 72°F
- Humidity : Ambient
- Photoperiod :12hrs light/12rhs dark
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Details on oral exposure:
- Using all available information on the toxicity of the test material, 2000 mg/kg was chosen as the starting dose.
dose level: 0, 500, 1000, 2000 mg/kg
concentration: 10 ml/kg - Doses:
- Single dose: 2g/kgBW at a dose level of 20ml/kgBW
- No. of animals per sex per dose:
- 5 females/males per dose
- Control animals:
- no
- Details on study design:
- All animals were observed frequently on day of dosing and daily thereafter for at least 13 days after treatment for a total of 14 days. Day of treatment = day 0.
Daily observations included signs of toxicity in addition to lethality.
Animals weighed on day 0, day 7 and day 13.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was 0 (zero) mortality
- Clinical signs:
- other: Decreased activity observed in all rats following treatment. Diarrhoea in 1 male and 2 females. Except for decreased activity in 1 female on day after treatment, all signs of toxicity were confined to the day of treatment.
- Gross pathology:
- No gross morphological abnormalities found.
- Other findings:
- No apparent effects on body weights or gross morphological abnormalities observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was greater than the limit dose of 2000mg/kgBW
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