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EC number: 940-783-4
CAS number: -
Test waived on the basis of the following. 1. strictly controlled conditions - exposure assessment is waived. 2. Acute to chronic ratio - looking at the data for Daphnia and algae, the acute to chronic ratios are Daphnia (31.7 mg/L/20 mg/L = 1.6) and algae (253.6 mg/L/81.3 mg/L = 3.1). These figures are very low (< 10) indicating that there is not that much difference between acute and chronic toxicity, showing that acute toxicity is the main mechanism of toxicity and is sufficient to represent the toxicity of the substance. 3. For ethical/animal welfare reasons, conducting an animal test would not add any additional value to the risk assessment process due to reason 2 above. 4. ECOSAR predicts 96 hr EC50 to fish for Bis (2-chloroethoxy) methane (125 mg/L) comparable to the measured value of 50.2 mg/L Predicted toxicity to fish of the other 2 main components (96 hr EC50: 610 mg/L and 225 mg/L) are all higher than that of Bis (2-chloroethoxy) methane. This supports the fact that acute toxicity to Bis (2-chloroethoxy) methane was used as a worst case in the dossier.
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