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EC number: 258-436-4 | CAS number: 53220-22-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 4.47 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.447 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 191.316 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 19.132 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 38.032 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential to cause toxic effects if accumulated (in higher organisms) via the food chain
Additional information
The PNEC derivation was as follows justified:
PNEC freshwater sediment:
K_(susp-water) = 10700
RHO_(susp) = 1150
Conversion factor (wwt -> dwt): 4.6
PNEC_freshwater sediment
= (K_(susp-water) / RHO_(susp)) * PNEC_water * 1000
= (10700/1150) * 0.00447 * 1000
= 41.59 mg/kg wwt
= 191.316 mg/kg dw
PNEC marine water sediment:
K_(susp-water) = 1.25
RHO_(susp) = 1150
Conversion factor (wwt -> dwt): 4.6
PNEC_marine water sediment
= (K_(susp-water) / RHO_(susp)) * PNEC_marine water * 1000
= (10700/1150) * 0.000447 * 1000
= 4.159 mg/kg wwt
= 19.1316 mg/kg dw
PNEC soil:
K_(soil-water) = 12800
RHO_(soil) = 1700
Conversion factor (wwt -> dwt): 1.13
PNEC_soil
= (K_(soil-water) / RHO_(soil)) * PNEC_freshwater * 1000
= (12800/1700) * 0.00447 * 1000
= 33.6565 mg/kg wwt
= 38.0318 mg/kg dw
Conclusion on classification
Acute aquatic toxicity:
96 h, LC50 (Danio rerio): >100 mg/L (nominal concentration)
48 h, EC50 (Daphnia magna): >100 mg/L (nominal concentration)
72 h, ErC50 (Pseudokirchneriella subcapitata): >100 mg/L (nominal concentration)
Aquatic chronic toxicity:
72 h, ErC10 (Pseudokirchneriella subcapitata): >100 mg/L (nominal concentration)
21 d, NOEC (Daphnia magna): 44.7 µg/L (time weighted average measured concentration)
35 d, NOEC (Danio rerio): >=403 µg/L (mean measured concentration)
Biodegradation: readily biodegradable: 65 % after 28 days (% degradation O2 consumption, OECD 301 D)
Partition coefficient: log Kow = >6.5 at 20 °C (estimated: 13 at 25 °C)
Classification according to CLP
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. The test substance was found to be readily biodegradable under the test conditions. In all aquatic tests the test item showed no toxic effect on the tested species. The determined (L)EC50 and EC10 for fish, Daphnia magna and green algae were >100 mg/L (nominal). The 21 d NOEC to Daphnia magna was determined to be 44.7 µg/L (TWA measured concentration). The 35 d NOEC in the FLES study was determined to be >= 403 µg/L for all measured parameters. Based on these results, the substance is not classified for short-term (acute) aquatic toxicity nor classified for long-term (chronic) aquatic toxicity according to Regulation (EC) No 1272/2008 (CLP), as amended for the eighteenth time in Regulation (EU) 2022/692.
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