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EC number: 258-436-4
CAS number: 53220-22-7
The acute oral toxicity of ditetradecyl
peroxydicarbonate was investigated in a group of five male and five
female CD rats at a dosage of 2000 mg/kg according to OECD guideline 401
and EU method B.1. The animals were starved overnight prior to dosing
and the test material was administered at a constant volume-dosage of 20
mL/kg in aqueous 0.5 % w/v methylcellulose.
Mortality and sings of reaction to treatment
were recorded during a subsequent 14 -day observation period. The
animals were killed on the following day and subjected to necropsy.
There was no death. Signs of reaction to
treatment were confined to piloerection in all animals on the day of
dosing. The animals were overtly normal on the following day. The
animals achieved expected bodyweight gains and necropsy revealed no
significant macroscopic lesion. The acute oral median lethal dosage
(LD50) of the test material was greater than 2000 mg/kg.
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