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EC number: 258-436-4 | CAS number: 53220-22-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-07-21 to 1992-10-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 84/449/EEC
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ditetradecyl peroxydicarbonate
- EC Number:
- 258-436-4
- EC Name:
- Ditetradecyl peroxydicarbonate
- Cas Number:
- 53220-22-7
- Molecular formula:
- C30H58O6
- IUPAC Name:
- 1-[({[(tetradecyloxy)carbonyl]peroxy}carbonyl)oxy]tetradecane
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River limited, Margate, Kent, England
- Age at study initiation: young adult
- Weight at study initiation: males: 112 - 123 g; females: 113 - 127 g
- Fasting period before study: overnight
- Housing: stainless steel grid cages
- Diet: commercially-available complete pelleted rodent diet was fed without restriction, except for removal of food for approximately 19 hours before aministration of the test material
- Water: free access to tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18 - 21 °C
- Humidity: 38 - 57 %
- Air changes: 15 complete air changes per hour without re-cicrulation
- Photoperiod: lighting cycle of 12 hours of artificial
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.5 % w/v
- Amount of vehicle: 20 mL/kg
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: on the day before dosing and on Days 1, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No rat died.
- Clinical signs:
- other: Signs of reaction to treatment were confined to piloerection in all animals on the day of dosing. The animals were overtly normal on the following day.
- Gross pathology:
- All animals were killed at termination of the study. Each animal was thoroughly examined for abnormality of tissues or organs.
All body cavities were opened, larger organs were selectioned and the gastro-intestinal tract was opened at intervals for examination of the mucosal surfaces. All abnormalities were described or the normal appearance of major organs was confirmed.
No tissues were retained in fixative.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral median lethal dosage (LD50) of the test material was greater than 2000 mg/kg.
- Executive summary:
The acute oral toxicity of ditetradecyl peroxydicarbonate was investigated in a group of five male and five female CD rats at a dosage of 2000 mg/kg according to OECD guideline 401 and EU method B.1. The animals were starved overnight prior to dosing and the test material was administered at a constant volume-dosage of 20 mL/kg in aqueous 0.5 % w/v methylcellulose.
Mortality and sings of reaction to treatment were recorded during a subsequent 14 -day observation period. The animals were killed on the following day and subjected to necropsy.
There was no death. Signs of reaction to treatment were confined to piloerection in all animals on the day of dosing. The animals were overtly normal on the following day. The animals achieved expected bodyweight gains and necropsy revealed no significant macroscopic lesion. The acute oral median lethal dosage (LD50) of the test material was greater than 2000 mg/kg.
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