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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Inhalation hazard test, saturated atmosphere was tested, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Principles of method if other than guideline:
Method: BASF test
GLP compliance:
no
Remarks:
GLP was not compulsatory at this time
Test type:
other: Inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibenzyldimethylammonium chloride
EC Number:
202-903-7
EC Name:
Dibenzyldimethylammonium chloride
Cas Number:
100-94-7
Molecular formula:
C16H20N.Cl
IUPAC Name:
dibenzyldimethylammonium chloride
Test material form:
liquid

Test animals

Species:
rat
Strain:
other: Gassner
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Details on inhalation exposure:
To generate saturated atmosphere, air was directed though a 5 cm layer of the test material at 20°C and 100°C respectively.
Duration of exposure:
8 h
No. of animals per sex per dose:
20°C vapour: 12 animals
100°C vapour: 12 animals
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
other: LT0
Remarks:
20°C vapour
Effect level:
13.75 mg/L air
Exp. duration:
8 h
Remarks on result:
other: no mortality observed
Dose descriptor:
other: LT0
Remarks:
100°C vapour
Effect level:
43.36 mg/L air
Exp. duration:
8 h
Remarks on result:
other: no mortality observed
Mortality:
No mortalities after 8-hour exposure to an atmosphere enriched with the test substance vapour generated at 20 and 100°C.
Clinical signs:
other: Irritation of mucous membranes was observed.
Gross pathology:
No adverse effects observed.

Applicant's summary and conclusion