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EC number: 202-903-7
CAS number: 100-94-7
Table 1: Mortalities
10 rats per sex and dose were exposed to single doses of 2500,
3200, 4000, 5000, 6400 and 8000 cmm/kg test substance/kg via gavage.
Directly after application accelerated breathing, tremors, apathy,
abdominal position and clonic convulsions were observed. Within a 7 -day
observation period, 2/20, 8/20, 19/20, 20/20, 20/20 and 20/20 animals
died in the dose groups of 2500, 3200, 4000, 5000, 6400 and 8000 cmm/kg.
Necropsy revealed venous congestion in deceased animals. A LD50 of 3300
cmm/kg was determined. The test material was an aqueous solution of the
test subtance, containing 50% test substance. It is unclear whether the
LD50 refers to the test material or pure test substance. Considering the
test substance density, the LD50 of 3300 cmm/kg was converted to 3630
mg/kg. Applying a worst case approach, the LD50 was corrected to 1815
mg/kg bw accounting for the water content in the test material.
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