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EC number: 701-281-9
CAS number: -
Table: Body weights and body weight gain
Individual data, means and standard deviations SD.
Body weight (g)
Body weight gain (g)
mg/kg (Step No.)
Table: Observations in life
A grade of severity was recorded where applicable
(low - mid - high).
Dose(mg/kg), Step No.
Observation time(p.a.)first last
signs of reduced well-being
21, 22, 23
1 h / 6 h
24, 25, 26
Table: Necropsy findings
Number of animals examined: 6 females.
no abnormal findings
The aim of the study was to investigate acute toxic effects of the
test substance after a single peroral administration to rats.
Methods and investigations were performed in conformance with the
OECD-Guideline 423, 17 December 2001 and theCouncil Regulation (EC) No
440/2008,Method B.1 tris.
Administration of the test substance
administered once orally via gavage as a solution in deionised water to
female Crl:CD(SD) rats.
The dosing was performed sequentially to groups of 3 animals per
step using a starting dose 2000 mg per kg body weight.
The dose volume was 10 mL per kg body weight for all groups.
weights: before administration, 7 and 14 days after the administration
observations: at least once per day.
The animals were sacrificed and necropsied 14 days p.a.
No. of animals
Presence of signs in life
from 1 h until 6 h p.a.
Full recovery of the animals
all animals gained weight in both weeks p.a.
Findings in life and post mortem indicate
no severe toxic effects present
LD50, oralaccording to OECD
> 5000 mg/kg body weight
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