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EC number: 218-235-4
CAS number: 2090-05-3
No abnormalities were reported during treatment.
No gross morphological changes during necropsy on day 10
In a dominant lethal assay, sodium benzoate was evaluated in rats. Male
rats (10/group) received 50, 500 and 5000 mg/kg bw as a single dose or
on 5 consecutive days by gavage. After treatment each male rat was mated
with two females per week for 7 -8 weeks (total 14 -16 females/male).
Females were examined for number of corpora lutea, early fetal deaths,
late fetal deaths and total implantations per uterine horn 14 days after
the mating period.
The test substance did not show any consistent statistical significant
effects on the parameters indicated above compared to negative controls.
Positive controls performed as expected. Therefore the result in this
dominant lethal test is considered to be negative.
Reliability of this study can be demonstrated as 2 (reliable with
restrictions) due to limited data available on methods and results.
Study predates approved guidelines and GLP.
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